Ann Pharmacother 2006;40(5):836-849. Br J Dermatol 2004;150:728-40. Taking evening primrose oil with phenothiazines might increase the risk of having a seizure in some people. HeadacheDon't take evening primrose if you have a bleeding disorder. Arch Dis Child 1996;75:494-7. View abstract. Gateley, C. A., Maddox, P. R., Pritchard, G. A., Sheridan, W., Harrison, B. J., Pye, J. K., Webster, D. J., Hughes, L. E., and Mansel, R. E. Plasma fatty acid profiles in benign breast disorders. Strong A and Hamill E. The effect of combined fish oil and evening primrose oil (Efamol Marine) on the remission phase of psoriasis: a 7-month double-blind randomized placebo-controlled trial. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Haimov-Kochman, R. and Hochner-Celnikier, D. Hot flashes revisited: pharmacological and herbal options for hot flashes management. View abstract. Roemheld-Hamm B, Dahl NV. Menendez JA, del Mar Barbacid M, Montero S, et al. Kruger, M. C., Coetzer, H., de Winter, R., Gericke, G., and van Papendorp, D. H. Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. View abstract. View abstract. View abstract. View abstract. Am J Psychiatry 1986;143(7):912-914. Engler MM, Engler MB, Erickson SK, Paul SM. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 44. 1999;13(7):627-629. View abstract. Belch JJ, Ansell D, Madhok R, et al. View abstract. 1987;62 Suppl 1:100-103. Kokke KH, Morris JA, and Lawrenson JG. Prog Lipid Res 1992;31(2):163-194. Seizures! Carter, J. and Verhoef, M. J. Efficacy of self-help and alternative treatments of premenstrual syndrome. View abstract. Hassig, A., Liang, W. X., and Stampfli, K. Bronchial asthma: information on phytotherapy with essential fatty acids. Sharif SN, Darsareh F. Impact of evening primrose oil consumption on psychological symptoms of postmenopausal women: a randomized double-blinded placebo-controlled clinical trial. Z.Hautkr. View abstract. View abstract. Evening primrose oil is generally well tolerated when taken in recommended dosages. 1986;15(1):114-115. Do not take fever plant, kings cureall, night willow herb, Oenothera biennis, scabish, stella di sera, or sun drop if you are allergic to evening primrose oil or any ingredients contained in this drug.. Keep out of reach of children. 1990;586:288-294. Anonymous. Am J Obstet Gynecol. These dietary supplements aren't necessarily harmless, though. Caution is advised in people taking drugs or herbs and supplements that lower blood pressure. 2009;19(1):43-46. Larsson B, Jonasson A, and Fianu S. Evening primrose oil in the treatment of premenstrual syndrome. Nutr Cancer 1995;24:33-45. . Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with EVENING PRIMROSE OIL. Lipids 1995;30(10):941-948. View abstract. Evening primrose oil may increase the effects of the HIV medicine lopinavir. View abstract. View abstract. View abstract. Tillett, J. and Ames, D. The uses of aromatherapy in women's health. View abstract. A prospective, double-blind, placebo-controlled multicentre clinical trial. Int.J Clin Pharmacol Ther. J Fam.Pract. Int J Surg Med. 1988;75(9):837-844. 1981;3(2):118-139. Am.J.Obstet.Gynecol. Berth-Jones, J., Thompson, J., and Graham-Brown, R. A. Keen H, Payan J, Allawi J, et al. View abstract. Barber A. But taking evening primrose oil doesn't seem to improve finger temperature or spasm of the blood vessels caused by cold. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. Peet M, Laugharne JD, Mellor J, and Ramchand CN. Cancelo Hidalgo MJ, Castelo-Branco C, Blumel JE, Lanchares Perez J.L, and Alvarez De Los Heros JI. Am J Obstet Gynecol 2002;187:1389-94.. View abstract. View abstract. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Side-effects are normally mild and include nausea, diarrhoea, indigestion and headache.19 Very rarely, EPO can cause an allergic reaction. Murray, T., Kelsberg, G., Safranek, S., and Crawford, P. Clinical inquiries. The Proceedings of the 4th International Benign Breast Symposium. Dr. Ed Friedlander answered. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. View abstract. 2017 Jan;28(1):4-15. Br J Surg. View abstract. Evidence-based treatment in family practice. Incidence of side effects is low. Scand.J Rheumatol.Suppl 1986;61:242-245. ).Some health conditions may make you more susceptible to the side-effects of the drug. Field, E. J. and Joyce, G. Effect of prolonged ingestion of gamma-linolenate by MS patients. View abstract. Cochrane Database Sys Rev 2012;(1):CD009560. 1998;36(7):363-366. [Evening primrose oil in neurodermatitis?]. Phenothiazines interacts with EVENING PRIMROSE OIL. Did you or will you purchase this product in-store or online? One person who was taking evening primrose oil and other medications had a seizure during surgery. Medications used during surgery (Anesthesia) interacts with EVENING PRIMROSE OIL. Read more: 8 Warning Signs of Depression You Shouldn't Ignore. In one study, infants fed this formula had better eyesight than infants fed regular formula, but not better than those who were breastfed. 1990;1(4):199-201. View abstract. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 46. Side effects, drug interactions, dosage, storage, and safety information should be reviewed prior to taking this supplement. Uccella, R., Contini, A., and Sartorio, M. [Action of evening primrose oil on cardiovascular risk factors in insulin-dependent diabetics]. Cochrane Database Syst.Rev. Belch JJ, Shaw B, O'Dowd A, Saniabadi A, Leiberman P, Sturrock RD, and Forbes CD. View abstract. The effects of gamolenic acid on adult atopic eczema and premenstrual exacerbation of eczema. [Flower essences: vibrational intervention of diagnostic and therapeutic possibilities]. Acta Obstet Gynecol.Scand 2005;84(10):972-979. Halat, K. M. and Dennehy, C. E. Botanicals and dietary supplements in diabetic peripheral neuropathy. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. 2016;2(2):83-88. Centre for Reviews and Dissemination. 2020;27(2):194-198. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Diabetes Care 1993;16:8-15. Ty-Torredes KA. Humphreys F, Symons J, Brown H, and et al. Early research shows that taking a specific evening primrose product 3 grams daily for 6 months improves dry eye symptoms in women wearing soft contact lenses. View abstract. For example, an October 2016 research paper published in Pharmacological Reviews assessed several herbal supplements and their role in women's health. Evening primrose oil (Efamol) in the treatment of children with atopic eczema. Moodley J and Norman RJ. A randomized, double-blind, placebo-controlled trial to evaluate efficacy and tolerability of an optimized botanical combination in the management of patients with primary hypercholesterolemia and mixed dyslipidemia. 2009;58(10):552-559. View abstract. Am J Obstet.Gynecol. View abstract. Belch J, Hill A. The effect of dietary supplementation with evening primrose oil of hyperkinetic children. Lancet 3-17-1990;335(8690):667-668. Aust N Z J Surg 1999;69:492-4.. View abstract. Ferrando, J. Prostaglandins Leukot Essent Fatty Acids 1990;40:199-202. The medicinal product is produced from the plant’s seeds. Surgeon. Clinical benefits of n-3 PUFA and gamma-Linolenic acid in patients with rheumatoid arthritis. Lipids 1987;22(12):1041-1044. Evening primrose oil for menopause is absolutely safe for the majority of people. Prostaglandins and premenstrual syndrome. Randomized trial comparing centchroman to evening primrose oil (letter). Aragona, P., Bucolo, C., Spinella, R., Giuffrida, S., and Ferreri, G. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren's syndrome patients. If you take any medications, consult your doctor before using EPO. Effect of exercise on FA profiles in n-3 FA-supplemented and -nonsupplemented premenopausal women. Gateley, C. A., Maddox, P. R., Mansel, R. E., and Hughes, L. E. Mastalgia refractory to drug treatment. Qureshi, S. and Sultan, N. Topical nonsteroidal anti-inflammatory drugs versus oil of evening primrose in the treatment of mastalgia. View abstract. View abstract. Casper RF and Powell AM. Holist.Nurs.Pract. A double- blind placebo controlled trial. In: Mansel RE (ed). Br J Clin Pharmacol 1985;19:335-42. Side Effects. 2008;74(5):447-452. But taking evening primrose oil might help to improve mood. View abstract. Phytother Res. View abstract. Puri BK. Simmer, K., Patole, S. K., and Rao, S. C. Long-chain polyunsaturated fatty acid supplementation in infants born at term. As the researchers note, this product doesn't seem to be any better than a placebo. View abstract. View abstract. 1988;118(3):449-451. Evening Primrose Oil Side Effects In studies, patients taking evening primrose oil have reported only minor side effects like headaches, nausea, upset stomach and loose stool [source: MedicineNet ]. A double-blind, randomized, placebo-controlled clinical trial. Allergic reactions are rare but possible. Effect of evening primrose oil supplementation on lipid profile: a systematic review and meta-analysis of randomized clinical trials. Effects of essential fatty acids on cyclical mastalgia and non-cyclical breast disorders. A learning disorder marked by difficulty reading (dyslexia). More than 90 percent of women experience bloating, mood swings, irritability, aches and other symptoms before and during their periods. Preece PE, Hanslip JI Gilbert L. Evening primrose oil (Efamol) for mastalgia. Drugs Exp Clin Res 1994;20:77-84. Am J Obstet Gynecol. Bassey EJ, Littlewood JJ, Rothwell MC, and Pye DW. Atherosclerosis 1989;75:95-104. View abstract. View abstract. 1991;14(9):282. Menopause: a review of botanical dietary supplements (;Provisional abstract). Das UN. Jones, L. Essential Fatty Acids and Dry Eye: What Do We Know? Douglas, S. Premenstrual syndrome. Lancet 5-26-1990;335(8700):1283. Br J Surg 1981;68:801. Terms of Use Evaluation and management of breast pain. Cont Lens Anterior Eye 2008;31(3):141-146. The effect of maternal supplementation with linoleic and gamma- linolenic acids on the fat composition and content of human milk: a placebo-controlled trial. Evening Primrose Oil is well tolerated and safe if used as recommended. Scand J Rheumatol 1983;12:85-8. Berth-Jones J, Graham-Brown RA. Jenkins AP, Green AT, and Thompson RP. Goyal, A. and Mansel, R. E. A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. View abstract. Quiz: What Do You Know About Vitamin B12 Deficiency? Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. Olsson, R., Tysk, C., Aldenborg, F., and Holm, B. View abstract. 1992;79(5):407-409. Kemmerich, B. View abstract. Hederos CA, Berg A. Epogam evening primrose oil treatment in atopic dermatitis and asthma. Therapeutic effects of precursors in the form of evening primrose oil (Oenothera)]. View abstract. View abstract. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. Researchers believe that it may be due to the hormonal changes occurring during the menstrual cycle. Rev.Esc Enferm.USP. High quality research shows that evening primrose is no more effective than a placebo (sugar pill) for reducing breast pain. Int.J Obes 1983;7(6):549-553. Evening primrose oil and magnesium have been shown to be effective. Sture, G. H. and Lloyd, D. H. Canine atopic disease: therapeutic use of an evening primrose oil and fish oil combination. Kelley, K. W. and Carroll, D. G. Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women. 2011;(2):CD002948. Zou L, Harkey MR, and Henderson GL. Side Effects of Evening Primrose Oil for Menopause. van Gool CJ, Zeegers MP, Thijs C. Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials. Hounsom, L., Horrobin, D. F., Tritschler, H., Corder, R., and Tomlinson, D. R. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. Lovell CR, Burton JL, and Horrobin DF. Journal of Reproductive and Infant Psychology 2006;24(4):363-378. Ann.Pharmacother. Clinical Uses of Essential Fatty Acids . Curr Ther Res 1989;46(1):58-63. Williams HC. North American Menopause Society. Whitaker DK, Cilliers J, de Beer C. Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. 2008;57(8):542-544. Clin Rheumatol 1989;8(2):238-244. Liver cancer. and Horner NK, Lampe JW. Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. Nat.Prod.Commun. Phytother Res 2012;26:265-272. Where did you or where do you plan to purchase this product? Br.J Hosp.Med 1990;43(5):330-332. Makrides, M., Neumann, M. A., Simmer, K., and Gibson, R. A. Erythrocyte fatty acids of term infants fed either breast milk, standard formula, or formula supplemented with long-chain polyunsaturates. An inherited skin disorder that causes dry, scaly skin (ichthyosis). EPO is a biennial plant native to North American but which is now found all over the world. Campbell ID, Stewart JCM, Royle GT, Taylor I. 1999. Can.J.Clin.Pharmacol. Immunomodulatory and therapeutic effects of Hot-natured diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Final report of a therapeutic trial. Cheema, D., Coomarasamy, A., and El Toukhy, T. Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review. Acta Derm Venereol Suppl (Stockh) 1985;114:143-145. View abstract. View abstract. J Reprod.Med 1997;42(10):637-646. Omega-6 essential fatty acids: pathophysiology and roles in clinical medicine. Evening Primrose oil, a dietary prostaglandin precursor diminishes vascular reactivity to resin and angiotensin II in rats. Oral omega-6 essential fatty acid treatment in contact lens associated dry eye. View abstract. Papas, E. Mcoptom D. Dry Eye and Diet: What Research Says About Essential Fatty Acids. J Hypertens 1992;10:1197-204. A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis. Additionally, there is a risk of allergic reactions, warns the European Medicines Agency. 2007;23(1):10-13. View abstract. Ann Med Psychol (Paris) 1983;141(8):883-891. View abstract. Central 1989;35. Aman MG, Mitchell EA, Turbott SH. 2001;44(4):853-863. View abstract. View abstract. View abstract. Ring, J. and Kleinheinz, A. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, Attention deficit-hyperactivity disorder (ADHD). In another clinical trial, EPO had no effect on PMS symptoms. Because evening primrose oil may cause uterine contractions, it is not recommended for pregnant women. Tomczyk, M., Zovko-Koncic, M., and Chrostek, L. Phytotherapy of alcoholism. View abstract. Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. View abstract. Little is known about the actual benefits of evening primrose oil. Control Clin Trials 1996;17:60-8. Behan PO, Behan WM, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. 1985;13(6):959-965. 1. Br Med Bull. 1995;6(4):209-212. Invest Ophthalmol.Vis.Sci 2005;46(12):4474-4479. Using EPO is a natural way to increase the chances of conception, as this oil is full … Lancet 7-7-1990;336(8706):50. Acta Chinese Medicine and Pharmacology 1993;21(4):37-38. A double-blind evaluation of evening primrose oil as an antiobesity agent. Manku, M. S., Horrobin, D. F., Morse, N., Kyte, V., Jenkins, K., Wright, S., and Burton, J. L. Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy. View abstract. View abstract. Ther Adv Psychopharmacol. J Investigative Dermatitis 1988;91(4):413. The basic side effects of evening primrose are rare and include the mild cases of stomach pain, headaches, nausea, and diarrhea. Vet.Rec. The studies cited in the above review had only a few participants and may not be conclusive. 1998;41(2):405-421. View abstract. Side Effects What are the side effects of Evening Primrose (Evening Primrose Oil)?. A movement disorder often caused by antipsychotic drugs (. Callender K, McGregor M, and Kirk P. A double-blind trial of evening primrose oil in the premenstrual syndrome: nervous symptom subgroup. Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: A double blind placebo controlled study. Huntley, A. L. and Ernst, E. A systematic review of herbal medicinal products for the treatment of menopausal symptoms. View abstract. Jaafarnejad F, Abidmoghaddam E, Emami SA, Saki A. The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. View abstract. Aust N Z J Surg 1994;64(5):329-331. This can cause symptoms such as sores on the fingers and toes. Mansel RE, Pye JK Hughes LE. Early research in children shows that applying evening primrose oil to water warts on the skin for 3 months might cause the lesions to disappear faster than doing nothing at all. Sharma N, Gupta A, Jha PK, Rajput P. Mastalgia cured! View abstract. evening primrose oil side effects on women. Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Barrett S. Primrose oil and eczema: How research was promoted and suppressed. Warren G, McKendrick M, Peet M. The role of essential fatty acids in chronic fatigue syndrome. The effect of gamma-linolenic acid on clinical status, red cell fatty acid composition and membrane microviscosity in infants with atopic dermatitis. 2018 Feb 9:1-5. Dante, G. and Facchinetti, F. Herbal treatments for alleviating premenstrual symptoms: a systematic review. View abstract. Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. Most of the time it happens because the dose is too high. Garcia C, Carter J, and Chou A. Gamma linolenic acid causes weight loss and lower blood pressure in overweight patients with family history of obesity. View abstract. Koshidawa N, Tatsuma T Furyya K et al. The effect of oral evening primrose oil on bishop score and cervical length amongst term gravidas. Evening primrose oil: a panacea? Br J Rheumatol 1991;30(5):370-372. When taken by mouth, it can sometimes cause mild side effects including upset stomach, nausea, diarrhea, and headache. Warnings. Budeiri D, Li Wan Po A, Dornan JC. Am Fam.Physician 12-15-2009;80(12):1405-1408. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing (abstract). View abstract. Anstey, A. Quigley M. Wilkinson J. D. Topical evening primrose oil as treatment for atopic eczema. Though rare, this herbal product may cause certain adverse effects. Some carry life-threatening side effects and may interact with dozens of medications. Horrobin, D. F. The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Acta Neurol Scand 1990;82:209-16. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. Evening Primrose Oil (Oenothera Biennis) is oil obtained from the seeds of a wildflower growing in the United States. Herbs of special interest to women. As mentioned earlier, this home remedy might increase bleeding. Copyright Policy J Am.Acad.Dermatol. A double-blind controlled trial of gammalinolenic acid (GLA) in the management of pre-menstrual gastrointestinal symptoms. Women Health 1992;19:117-31. Diabet Med 1990;7(4):319-323. Negative effects from taking evening primrose oil for weight loss are mild digestive issues and headaches. View abstract. Prostaglandins Leukot Essent Fatty Acids 1996;55(1-2):71-75. Life Sci 8-16-2002;71(13):1579-1589. Am J Clin Nutr 2000;71:323S-6S. Vaddadi KS. Online ahead of print. View abstract. Health Technol Assess 2000;4(37):1-191. Martens-Lobenhoffer, J. and Meyer, F. P. Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). 2003;16(1):47-57. View abstract. Most subjects reported mild and temporary side effects, such as diarrhea and indigestion. Effectiveness of a herbal formula in women with menopausal syndrome. Treatment of diabetic neuropathy with gamma-linolenic acid. used as a substitute for professional medical advice, Yakoot M, Salem A, and Omar AM. 2000;(2):CD001257. Br J Surg. Herbs, menopause, and dialysis. View abstract. Andra Picincu is a certified nutritionist and personal trainer with more than 10 years of experience. Taking evening primrose oil doesn't seem to reduce blood pressure in women with pre-eclampsia. Information from this source is evidence-based and objective, and without commercial influence. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. Laugharne, J. D., Mellor, J. E., and Peet, M. Fatty acids and schizophrenia. The hypotensive effect of dietary gamma-linolenic acid and associated alterations in tissue fatty acid composition and the Renin-Angiotensin system. 2009;12(5):394-401. In some cases, primrose oil may cause side effects such as stomach upset, headache, nausea, and diarrhea.2 Most of the side effects are low-grade and resolve on their own once the treatment is stopped. However, the study had only 40 participants, so its findings require further investigation. Endres, S., Lorenz, R., and Loeschke, K. Lipid treatment of inflammatory bowel disease. van der Merwe, C. F. Booyens J. Parveen, S. Sarwar G. Ali M. Channa G. A. Danazol versus oil of evening primrose in the treatment of mastalgia. Stordy BJ. Before using Evening Primrose Oil, inform your doctor about your current list of medications, over the counter products (e.g. Rheumatology. View abstract. Phytother.Res 2009;23(12):1647-1662. Symptoms of menopause. View abstract. Viikari J and Lehtonen A. J Am Diet Assoc 2000;100:1368-80. J Orhtomolecular Psych 1983;12:302-304. Menopause. View abstract. View abstract. Med Cutan.Ibero.Lat.Am 1986;14(2):133-137. Taking evening primrose oil along with medications that also slow clotting might increase the chances of bruising and bleeding. Menendez JA, Colomer R, Lupu R. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-Linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells. van der Merwe CF, Booyens J, Joubert HF, van der Merwe CA. Med Monatsschr.Pharm. As the scientists point out, EPO is rich in beta-sitosterol, ferulic acid and other bioactive compounds with therapeutic properties. In April 2013 analyzed 27 studies assessing the long-term safety of evening primrose oil is safe. Gynaecol 2006 ; 195 ( 6 ):629-635: CD004416 parveen, S. E. and Church,,! Avoided by anyone who suffers a seizure during surgery ( Anesthesia ) interacts with evening primrose for PMS topical anti-inflammatory... 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